Introduction. T-2 toxin is the most toxic and widespread fusariotoxin in temperate regions of Russia and Europe. It has a polytoxic effect and leads to apoptosis of hepatocytes, other cells of internal organs and changes in the biochemical parameters of blood serum. The purpose of the study was to evaluate the effectiveness of specific (immune) therapy for rabbit mycotoxicosis using biochemical markers of the functional capacity of internal organs. Materials and methods. For the experiment, 4 groups of male rabbits were formed, 5 animals each. The first group was a negative control. The diet of rabbits of the second, third and fourth groups consisted of combined fodder contaminated with T-2 toxin at a dose of 0.3 mg/kg of feed. Rabbits of the third group underwent a course of passive serum immunization containing polyclonal antibodies to the conjugate of T-2 toxin with polylysine at the beginning of the experiment and again on 7th and 14th days of the experiment. Animals of the fourth group underwent a course of active immunization before the introduction of the toxin with the conjugate of T-2 toxin with polylysine. On the 21st day of the experiment, blood serum was taken from animals to determine serum urea, total protein, glucose, cholesterol, and the activity of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. Research results, discussion. As a result of the experiment, it was demonstrated that specific therapy in the form of therapeutic serum containing polyclonal antibodies to T-2-polylysine conjugate provides protection against mycotoxicosis of animals. With preliminary (active) immunization of rabbits with T-2 polylysine conjugate, the action of T-2 toxin is also neutralized, but the effect is less than with the first therapy.