Introduction. Mycotoxins have a negative effect on animals, affecting vital organs, causing disorders of lipid and protein metabolism. Mycotoxins often occur in combination, having a synergistic or additive effect on animals. However, the pathogenesis of combined effects has not been sufficiently studied. An effective way to prevent mycotoxicoses is to use preparations of complex action having in their composition substances with pathogenetic and symptomatic effects. The aim was to study the changes in lipid and protein profile parameters in white rats at T-2, afla- and zearalenontoxicosis and evaluate the efficiency of combined prophylactic agents. Materials and methods. White rats were divided into 8 groups: 1 ‒ biological control; 2 ‒ toxic control (T-2 toxin + zearalenone + aflatoxin B1); 3 ‒ toxic control + preventive complex No. 1 (PC 1: β-glucans, milk thistle meal, vitamin E, ascorbic acid, levamisole); 4 ‒ toxic control + preventive complex No. 2 (PC 2: bentonite, succinic acid, methyluracil, vitamin A, probiotic preparation “Florin”); 5 ‒ toxic control + preventive complex No. 3 (PC 3: halloysite, methionine, β-glucans, milk thistle meal); 6 ‒ biological control + PC 1; 7 ‒ biological control + PC 2; 8 ‒ biological control + PC 3. Research results. The efficacy of the proposed prophylactic complexes in experimental T-2, afla- and zearalenontoxicosis in white rats was revealed, with a group priority using the third formulation based on the natural mineral halloysite. The application of prophylactic complexes at a dose of 0.25 % of the diet had a normalizing effect on lipid metabolism.