Introduction. Under certain conditions, the main source of energy in the diet of cattle may be concentrated feed, such as cake, meal and legumes. With their excess in the rumen, acidic metabolic products are formed during digestion, which block the reproduction of normal microflora in the rumen. Therefore, feeding acidic silage and excess concentrates in the diet contributes to the development of rumen acidosis. Rumen acidosis is the beginning of a number of diseases, such as: atony of the pancreas, osteodystrophy, ketosis, hepatosis. All these pathologies are accompanied by a decrease in milk productivity. The purpose of this work is to conduct a comparative analysis of various treatment regimens for acidosis of the rumen of cows. Materials and methods. We conducted 2 series of experiments on cows with rumen acidosis. In the first series, we studied the effectiveness of oral administration of sodium acetate at doses of 0.4g/kg, 0.5 g/kg and 0.6 g/kg of body weight in rumen acidosis. In the second experiment, we studied the effectiveness of oral administration of calcium acetate at doses of 0.2 g/kg, 0.3 g/kg and 0.4 g/kg of body weight. Research results, discussion. In the first experiment, it was found that the effectiveness of sodium acetate in rumen acidosis was practically identical when using 0.5 and 0.6 g/kg. In 83.3 % of cases, a single application of sodium acetate led to recovery. The average duration of recovery of the motor function of the rumen was 410 minutes. It was revealed that in comparison with sodium acetate, the effect of calcium acetate is significantly more effective after 1−2 applications of calcium acetate at a dose of 0.3 g/kg. Conclusion. With oral administration of sodium acetate and calcium acetate with acute atony of the rumen, it is possible to normalize the motor function of the rumen, rumen digestion in general, alkaline reserve, glucose level. The duration of the period for the restoration of the motor function of the rumen when treated with sodium acetate is six to eight hours, when using calcium acetate – two to three hours.