The aim of the research was to study the influence of genetic factors (genotype, line of the stud bull, productivity of female ancestors) on longevity and lifelong productivity of cows of black-and-white breed. Retrospective data analysis of breeding records for retired cows at ZAO BF “Semyonovsky” in the Republic of Mari El was carried out. A reliable effect of the genotype and linear belonging of bull-fathers on productive longevity and lifelong milk yield of daughters was established. The descendants of purebred bulls of black-and-white breed for 6.09 lactations milked 33437 kg of milk, which is 2.56 lactations and 11510 kg of milk more than peers. The daughters of the A. Adem line bulls were characterized by the longest period of use (6.83 lactations) and high lifelong milk yield (43037 kg). For a long period, 5.95 lactations with a lifetime milk yield of 36075 kg of milk, the descendants of bulls, from mothers with low productivity, were exploited. As the longevity of the bulls’ mothers increased, the period of productive use and the lifetime milk yield of the bulls’ daughters increased. Depending on the quality of cow-mothers, a pattern of changes in the indicators of productive longevity in daughters was revealed. Daughters from the worst cows-mothers were less active in milking, but had high productive longevity (4.0 lactations). With an increase in the productivity of mothers, daughters increased the intensity of milking and milk yield for the 1st lactation, but the period of operation was reduced. There was a positive correlation “mother-daughter” (r = +0.18) in milk yield for the 1st lactation, and negative correlation – milk yield for the 1 lactation of mothers with productive longevity (r = –0.24) and lifetime milk yield (r = –0.21) of daughters. The proportion of mothers’ influence on the analyzed signs was low.