Introduction. In the modern world, environmental pollution by various chemical xenobiotics is a threat to the environment and adversely affects the health of people and animals. Under the conditions of anthropogenic load on agricultural systems, the issue of the production of biologically valuable and environmentally safe agricultural products is particularly acute. The success and prospects for the use of chelation at the present stage are unquestionable. The use of such tools in practice turned out to be the most productive in chronic intoxications with compounds of radioactive elements, mercury and lead. Objective. To study the migration dynamics of chemical xenobiotics in the liver, kidney and muscular tissue of guinea pigs and, against the background of migration, the effect of the sodium salt of oxyethylidenediphosphonic acid. Materials and methods. The objects of research were guinea pigs. Two series of experiments with the inclusion in the diet of animals of feed grown with different doses of sewage sludge and with the addition of complexon – sodium oxyethylidenediphosphonic acid (Na-OEDPА) to the diet were conducted. At the end of the experiment, in order to study the internal organs and muscle tissue for the content of chemical xenobiotics, slaughter was carried out, followed by dissection of animals. The content of lead, cadmium, copper and zinc was determined by the atomic absorption method on a “Kvant-Z. ETA-1” spectrometer; mercury – on the analyzer “Julia”, and the arsenic content – by colorimetric method. The results of the discussion. The absorption rate of heavy metal compounds is influenced by the biological characteristics of the digestive organs, the physicochemical properties of these substances, etc. Complexons, taking part in complex reactions, interact with various compounds of inorganic and biological nature. The role of complexones is to maintain the metal ligand homeostasis in the body, as well as the removal of toxic metal ions from it. The study of muscle tissue, internal organs (liver, kidneys) of laboratory animals, when sodium salt of oxyethylidenediphosphonic acid was added to their diet, indicated a decrease in the content of toxic elements. Conclusion. It was found that toxic elements in the liver, kidneys and muscle tissue of guinea pigs accumulated unevenly. It was revealed that the content of cadmium exceeded the maximum permissible level in the liver by 1.40 times, in the kidneys by 1.34, in muscle tissue by 1.20 times. The maximum zinc content of 100.82±1.33 mg/kg at a PL of 100 mg/kg was found in the kidneys of animals from the fourth experimental group. The excess of PL in the studied tissues and organs of animals on the content of lead, mercury, copper and arsenic was not found. The addition of sodium salt of oxyethylidenediphosphonic acid to the diet of laboratory animals allowed to reduce the content of toxic elements in animals by an average of 1.2–4.4 times. The optimal dose of the drug was 1.5 g per 1.0 kg of feed.