Introduction. The article shows the problems of adaptation of the Russian agro-industrial complex (AIC) to the conditions of sanctions pressure, and also identifies the prospects opening up for the agro-complex in new conditions, considers a number of key problems, including: disruption of logistical supply chains of agricultural products, difficulties with the import of seeds, feed additives, machinery and technologies. Among the main opportunities for development, the following are highlighted: increasing the efficiency of the seed industry, developing the agricultural machinery and equipment production, expanding domestic agricultural enterprises into new markets, etc. The purpose of the work is to analyze the problems of adaptation of enterprises of the Russian agro‒industrial complex (AIC) to the conditions of sanctions pressure on our country and assess the prospects that open up to the domestic agricultural complex in the new conditions. Materials and methods. The work uses materials from the periodical press, mass media, and official statistical data on the activities of the Russian agro-industrial complex, including in the context of the constituent entities of the Russian Federation. Research results, discussions. Since the agro-industrial complex of the Russian Federation was seriously dependent on the supply of agricultural products, imported seeds, feed additives, machinery and technologies, it became necessary to assess the main opportunities for the development of the domestic agro-industrial complex in these problem areas, in connection with which, development directions were identified, consisting in increasing the efficiency of the seed industry, the expansion of agricultural enterprises into new markets, in search of new supplies of necessary logistical resources in friendly countries. Conclusion. Thus, under the current conditions, it is necessary to ensure state support for the industry, stimulate investment, ensure effective import substitution and dynamic technological development of agricultural enterprises, and work out mechanisms for the expansion of Russian agricultural producers into new foreign markets.