Introduction. Recently, much attention has been paid to the use of antioxidant agents, the effectiveness of which is associated with the effect on the universal pathogenetic link ‒ oxidative stress that develops in metabolic diseases. The purpose of the study is to evaluate the effect of succinic acid and butophosphan on prooxidant-antioxidant status in newly-calved cows and on the organism of newborn calves obtained from them. Materials and Methods. Scientific research was carried out in 2023 in the farm Churin P. I. of the Chistopol rergion, Republic of Tatarstan on Holstein-Friesian cows aged 3‒5 years, of average and above average fatness, body weight 500‒700 kg, with average annual dairy productivity of 9000 kg, divided into two groups. One of them was treated with “Yantovet” at a dose of 20 ml per animal, in the last month of pregnancy three times at a dose of 20 ml/head with an interval of 7‒10 days. The second group served as a control. Indicators of lipid peroxidation were determined in whole blood of animals. Malonic dialdehyde was determined using the thiobarbituric acid reactive substance assay. Superoxide dismutase activity was determined by spectrophotometric method, according to the degree of inhibition of the quercetin oxidation reaction. Catalase activity was determined by the Korolyuk method. Research results, discussion. The use of “Yantovet” in a dose of 20 ml /head to dry cows three times in the last month of pregnancy helps to reduce the processes of lipid peroxidation and increase the activity of the enzymatic antioxidant system of the blood in cows, and as a result, increase the morphofunctional status of calves at birth, as evidenced by a higher body weight at birth of calves by 16.5 %, an increase in the intensity of growth by 4.6 %, a decrease in the number of cases of gastrointestinal diseases in the neonatal period by 13.4 %.