Mycotoxins are secondary metabolites of mold fungi and cause great economic damage, impairing the produc-tivity and conversion of feed, reducing immunity and reproductive function, increasing the cost of treating an-imals. Despite the growing list of pharmacological drugs for the treatment of mycotoxicosis, the choice of effec-tive means of protection against mycotoxins is still extremely insignificant, since no specific prevention has yet been developed. This article evaluates the effectiveness of specific polyclonal serums in animal mycotoxicosis. To set up the experiment, 4 groups of white rats were formed. The first group of animals served as biological control, the rats of the second group received T-2 toxin in the form of a 5% water-alcohol solution at a dose of 1/20 LD50, the third group received T-2 toxin in a similar dosage and treatment in the form of injections of poly-clonal serum at a dose of 0.3 ml per kg of body weight on the first, seventh and fourteenth days of the experi-ment, the fourth was injected polyclonal serum at the same time and dosages. As a result of gravimetric studies, it was found that by the end of the experiment, the rats of the second group had a body weight loss of 36,5 % (p<0,001) compared to the control group, while against the background of treatment - 13,8 % (p<0,01). Based on the results of hematological and biochemical studies of the blood of experimental animals, an improvement in the homeostasis of the body and the metabolic function of liver was established. The results of the study jus-tify the expediency of using specific treatment based on specific polyclonal serums for the treatment of myco-toxicosis in animals.