The effect of fertilizers and precursors on the yield and chemical composition of spring wheat has been studied. It was revealed that a higher yield of spring wheat grain up to 3.22 t/ha was obtained in a favorable 2013. In 2014 and 2015, the grain yield was lower and did not exceed 2.71 t/ha. Mineral fertilizers had a positive effect on the formation of spring wheat grain yield. On average, over 3 years, the gains from their use, depending on their predecessors, ranged from 0.66 t/ha to 0.88 t/ha. When cultivating spring wheat, both without the use of mineral fertilizers, and against the background of N30P60K60, the smallest amount of protein, respectively 13.3 % and 14.3 %, gluten − 24.0 % and 26.9 %, and the weight of 1000 grains − 40.1 g and 41.7 g, had grain grown when placing spring wheat on the cereal predecessor.When cultivating spring wheat on red clover without the use of mineral fertilizers, the protein content in the grain increased to 13.5 %, and when they were used to 14.6 %. The amount of gluten increased and amounted to 24.8 % and 27.4 %, respectively. The weight of 1000 grains was 41.5 % and 43.5 %, respectively. The cultivation of spring wheat by legume-cereal grass mixture en-sured the accumulation of protein in the grain on a non-fertilized background of 13.5 %, and with the use of mineral fertilizers 14.6 %. The gluten content in the grain was 24.3 % and 27.2 %, respectively. The weight of 1000 grains in the cultivation of spring wheat without the use of mineral fertilizers was 41.3 %, and when they were used 43.1 %.