Abstract. Renal anemia is one of the many complications of renal parenchyma destruction, which significantly reduces the quality of life of animals, in addition, it is one of the factors that worsen the disease prognosis. Renal anemia usually develops in patients with severe structural changes in the renal parenchyma and is directly related primarily to erythropoietin deficiency. In the vast majority of cases, the nosological form of nephropathy that led to this type of anemia is chronic kidney disease (CKD). However, the severity of this complication depends on the variability of the renal parenchyma lesion, as well as on other features of the course of CKD in a particular patient. In this regard, the aim of our study was to study the effectiveness of recombinant erythropoietin for the correction of anemic syndrome in CKD. Twenty cats of various breeds were selected for research on the principle of analogues, which were diagnosed with chronic kidney disease during a comprehensive assessment of the condition using clinical, hematological and functional research methods, in addition, these animals had a decrease in the level of red blood cells, hemoglobin and hematocrit, which required correction of the anemic syndrome. Recombinant erythropoietin was administered to 10 animals of the experimental group at a dose of 50 IU/kg 3 times a week against the background of the standard treatment regimen, which included the use of diet therapy, etiotropic, substitution and symptomatic therapy, which was also received by 10 animals of the control group. Treatment and animal studies carried out over 90 days showed that the normalization of the clinical condition of CKD patients and the stabilization of certain parameters of the biochemical status occurred in animals of both groups, but the dynamics was more pronounced in animals of the experimental group. Under the influence of erythropoietin, morphological parameters of blood (red blood cells, hemoglobin, hematocrit) in animals of the experimental group reached the normative limits, while in the control group, the lack of correction of this link of pathogenesis led to their decrease, and therefore the general treatment regimen also did not give full therapeutic effectiveness.