Introduction. Currently most of the potatoes are grown in the private sector, where the cultivation technology is violated, crop rotation is not respected, and protective measures are not sufficiently taken. This leads to a deterioration of the phytosanitary state of crops and decrease of potato tubers yields and quality. Violation of zonal technological regulations for potato cultivation resulted in a rapid increase in disease harmfulness. One of the most dangerous potato diseases is late blight. Currently, the drug market offers more than twenty types of drugs, but practice shows that not all drugs effectively protect potatoes from late blight. The aim of the research is to establish the effectiveness of fungicides against potato late blight. Materials and methods. Experiment scheme: 1) control (without spraying); 2) Ridomil Gold MC, WDG (2.5 kg/ha); 3) Profit Gold, WDG (0.6 kg/ha); 4) Ordan, WP (2.0 kg/ha). It was microplot experiment in 4 replicates. The potato variety Gala was used in the experiment. Fungicide spraying was performed by backpack sprayer on windless evenings. Research and discussion results. The least spread of potato late blight was in the variant with Ridomil Gold. Compared with the control, the prevalence of late blight decreased by 4 times in the first registration and by 5 times in the second registration. The biological efficiency of Ridomil Gold MC was 85 %, of Profit Gold was 78 %, and of Ordan was 49 %. In the variant with Ridomil Gold MC, potato yield increased by 5.4 t/ha compared to the control. The highest profitability of potato production was obtained in the variant with Ridomil Gold MC fungicide spraying. Conclusions. Fungicides have different efficiency against potato late blight. The best result was obtained from Radomil Gold MC fungicide.