Modern poultry farming and cattle breeding can no longer be imagined without special feed additives and various protein, vitamin and mineral complexes. This is not the desire of farmers to get a high result by all means, but a scientifically based decision that makes agriculture effective. A special place among all the additives is protein-vitamin-mineral concentrate, which gives the bird and cattle all the most necessary and vital substances. To date, the concentrate formulation is standardized, and its use allows to provide a full-fledged ration of poultry and livestock. The protein-vitamin-mineral concentrate includes components with a high protein content, biologically active additives, micro- and macroele-ments, and a vitamin complex. The necessary con-tent of proteins, vitamins and minerals is achieved using components of animal and vegetable origin, as well as products of microbiological synthesis. This article presents the results of the influence of the vitamin and mineral complex “Sapromix” on the metabolism in cows. The experiments were carried out in LLC “Dairy products” of the Soviet region of the Republic of Mari El. 36 cows of black and motley breed were selected taking into account milk production, breed, age, body weight and physiologi-cal state. According to the experimental scheme, the cows of group 1 received the basic balanced diet throughout the experiment. Cows of 2 and 3 experimental groups got in the diet 2 and 4% of “Sapromix” equivalent to the mass for 1 kg of dry matter, respectively. Studies have established that the use of the vitamin and mineral complex “Sapromix” had a positive effect on the metabolism in cows, which affected the changes in protein and mineral metabolism.