The article is devoted to the experience of the biologization of agriculture on the example of LLC “Agrofirma “Glory to the Potato” of the Chuvash Republic. LLC “Agrofirma “Glory to the Potato” of the Chuvash Republic is specialized in the production of crop products and, above all, on large-scale potato and grain production. There is no cattle-breeding industry in the economy, no manure. Therefore, for successful production in the present and the future, the central issue is the reproduction of fertility on the basis of a large-scale return to the soil of organic matter. The aim of the research is to study the possibility of biologizing crop rotations. In each rotation, the obligatory condition is the presence of long-term leguminous or leguminous grasses and the introduction of straw and manure fertilizers into the soil, primarily to improve the balance of humus and soil biological parameters. 36.6 kg of nitrogen, 16 kg of phosphorus and about 66 kg of potassium were returned to the soil in the area of cultivation of cereals and peas with straw, on average per hectare. The share of the clover in the structure of sown areas is 21.3%. The amount of nitrogen, phosphorus and potassium supplied by the gray wool melon in yellow in 2016 in the agrofarm for 1200 hectares is equivalent to: 1055 tons of ammonium nitrate in nitrogen, 194 tons of superphosphate in phosphorus, 470 tons of potassium in potassium. Radish olive oil for repeated sideration after embedding in the soil of the clover organics in 2016 was sown at the beginning of the third decade of June on an area of 429,6 hectares. Thanks to the use of straw and widespread introduction of sideration in agrofarm farming, a positive balance in nitrogen and potassium has been achieved. At the same time, the share of biological nitrogen in the balance sheet was 76,3 %, and the mineral fraction only 23,7 %, respectively, 42,6 % phosphorus and 68,0 % potassium. Obligatory elements of the technology should be pre-sowing treatment of the tubers with bioregulators in doses: Propastin – 2,3 liters/10 liters of water per 1 ton of tubers; Fumar – 30 ml/10 l of water per 1 ton of tubers; Non-root processing of vegetating plants in the budding phase: Polystin – 3l / 300 liters of water per 1 ha, Intermag Potato – 2l / 300 liters of water per 1 ha.