Disease root rot of cereals is the most common disease, both in Russia and abroad. As a result, this disease affects the root system of plants, which inhibits their normal devel-opment and growth, and in the case of severe lesions, yield of crops may be reduced by 50 percent or more. The wide distribution and high severity of the disease has necessitated the development of effective control measures, due to the fact that the inoculum may stay for a long time, stored at different depths in the soil, therefore, chemical protection against diseases is ineffective. The article is devoted to the analysis of the biological method of fighting based on the use of soil fungi biological agents against soil phyto-pathogens, where these principles are based on phenomena such as hyperparasitism and antibiosis between microor-ganisms, representing saprotrophs, parasitic and pathogenic microbiota of the soil. The use of closely related species of fungi of hypoallegenic or avirulent strains of the pathogenic may result in the phenomenon of induced resistance of the host plants to fitopatogene. Competition for living space between virulent and avirulent strains in the rhizosphere of roots of plants plays a role to reduce the level of destruction of plants. Thus, fungi are promising agents against root rots of cereal crops, and the soil for them, it's natural habitat, but considering, that cereal crops are cultivated in different soil-climatic conditions, it is obtain a universal bioagent. For the development of technologies of application of biological products it is necessary to know the physico-biochemical factors of the process of colonization of the roots and specificity of the most effective strains.